Name of the Project with IRN number
AP26198287 Development of original synthetic antimicrobial/antifungal drugs for the needs of medicine and/or agriculture.
Relevance/Abstract
With the introduction of new classes of antibacterial agents, the phenomenon of antibiotic resistance is becoming more pronounced and significant. Currently, to solve the problem of resistance, work is underway on the synthesis of drugs with high activity, the development of new dosage forms of drugs, the selection of optimal dosage regimens, and the preparation of drugs for the treatment of infections caused by resistant strains, in particular, staphylococcus.
The search for new compounds with antimicrobial, fungicidal, and viricidal effects is one of the most priority areas in the development of anti-infective drugs. The importance of chemoprophylaxis and chemotherapy as a way to combat bacterial infections cannot be overestimated.
The project is aimed at solving urgent problems of scientific, technical and socio-economic development of the Republic of Kazakhstan, as it aims to synthesize new potentially biologically active and low-toxic drugs that are more effective than those used in practice.
The problems that the goal is aimed at investigating. The previously obtained results will be taken into account in the design of new biologically active C-, O-, N-substituted heter derivatives to increase bioactivity and reduce toxicity. Nitrogenous heter derivatives are hydrophobic by nature, and studies on complexation with β-cyclodextrin will be conducted to convert substances into a soluble form.In the planned research, it is assumed, among other things, to obtain new heter derivatives with low solubility in water, like their predecessors. The solution to this problem will be solved by studying their complexation with a medical polymer using the pH-metric method.
To complete the research, it is necessary to develop existing experimental techniques and describe the physico-chemical features of heterocyclic derivatives. For the construction of biologically active heterocyclic derivatives: the use of several complementary experimental methods; complication of the structure of heterocycles, the study of their structural and chemical features.
The methodology used for the implementation of the project consists in the synthetic construction with extensive use of classical synthetic methods of fine organic synthesis (CBT) of new structures by involving various reaction centers of the initial objects in the reaction and introducing structural fragments responsible for a particular type of biological action, in particular, with antimicrobial/antifungal activity.
The creation of new antimicrobial/antifungal drugs corresponds to the state concept of the country's transition to a "green economy". The development of new antimicrobial/antifungal drugs is of great social and technological importance both for the Republic of Kazakhstan and in the world. The Project will develop new candidate substances for antimicrobial/antifungal drugs for the needs of medicine and/or agriculture.
The relevance and prospects of this area of work are undeniable. As a result of the proposed research work, using the achievements of science in recent years, it is planned to develop new dosage forms of biologically active heterocyclic derivatives and establish the structure and composition using various physical and physico-chemical analysis methods.
Purpose (according to application)
The aim of the project is to create synthetic ways to obtain new organic structures with potential antimicrobial/antifungal activity, identify structural fragments and their combinations in the manifestation of a particular bioactivity by the method of directed molecular design.
Expected results
Expected results: an algorithm of structural fragments in the manifestation of bioactivity will be created, a scientific bank of new pharmacologically active substances in a number of nitrogenous heterocycles will be created to develop new original domestic antimicrobial/antifungal drugs for the needs of medicine and/or agriculture based on a number of new multifunctional systems designed within the framework of the project;
The results of the project should increase the scientific and technical potential and competitiveness of scientific organizations, as the project aims to supplement the practical results and experimental data on piperidine-containing azaheterocycles, and to obtain information about the alleged valuable antimicrobial/antifungal biological properties of new products.
List of full names of research team members with their identifiers (Scopus Author ID, Researcher ID, ORCID, if available) and links to relevant profiles
Praliyev Kaldybay Dzhaylovovich – Researcher ID: GBS-0012-2022, Scopus Author ID: 6603014171, ORCID: 0000-0003-0381-7481
Akhmetova Gulmira Serikovna – Researcher ID: CAX-8607-2022, Scopus Author ID: 57196043779, ORCID: 0000-0002-9074-1464
Issayeva Ulzhalgas Bakytzhankyzy – Researcher ID: CVC-0767-2022, Scopus Author ID: 57210920401, ORCID: 0000-0001-6976-6096
Malmakova Aigul Erbosynovna – Researcher ID: ABE-6190-2021, Scopus Author ID: 56436775600, ORCID: 0000-0001-9996-9476
Datkhayev Ubaidilla Makhambetovich – ResearcherID S-1732-2018, Scopus Author ID: 55777169700, ORCID: 0000-0002-2322-220X
Omyrzakov Manas Toktasynovich – Researcher ID: GZA-6033-2022, Scopus Author ID: 56127298500, ORCID: 0000-0002-2665-178X
Seilkhanov Olzhas Tulegenovich – Researcher ID: O-6394-2017, Scopus Author ID: 56711954500, ORCID ID 0000-0002-2322-8863
Yskakbayeva Zhanar Alibayevna – Scopus ID: 57216252051, ORCID: 0000-0001-7428-0074
Zhaumitbaeva Gulzia Allayerkyzy – ORCID: 0009-0006-2522-204X
