«Targeted modification of natural alkaloids and their synthetic analogues into agents of a given type of action» (2024-2026 гг.) IRN AP23484420

Name of the Project with IRN number

«Targeted modification of natural alkaloids and their synthetic analogues into agents of a given type of action» (2024-2026 гг.) IRN AP23484420

Relevance/Abstract

Natural alkaloids and their synthetic analogues represent a unique source of biologically active compounds with diverse pharmacological properties. However, to improve their therapeutic efficacy and reduce side effects, a targeted modification is often required to achieve a specific type of activity. The ability of alkaloids to interact with various targets in the cell creates unique opportunities for the modification and creation of preparations with the targeted activities. At the same time, their synthetic analogues provide researchers with the opportunity to structurally optimize and create compounds with the desired pharmacological properties. This contributes to the development of preparations with the improved bioavailability, selectivity and stability. The targeted modification in this case involves changing the structure of alkaloids in order to enhance or reduce their effect on specific biological targets.

Purpose (according to application)

Applying modern theoretical, experimental methods to targeted search for BAS, to obtain agents of given type of activity (local anesthetic, myelostimulating, plant growth stimulating activities) by modifying natural alkaloids and their synthetic analogues, to identify some regularities of the effect of functional-groups on their biological activity.

Expected results

1) New modified derivatives of natural alkaloids and their synthetic analogues with a confirmed structure and detailed physicochemical properties, which have been tested for a biological activity;

2) An optimally selected or developed method for the synthesis of the derivatives of natural alkaloids and their synthetic analogues, especially based on the principles of green chemistry;

3) Establishing “the structure of derivatives of natural alkaloids and their synthetic analogues - biological activity correlation”, identifying the effect of replacing some pharmacological groups with myelostimulating, local anesthetic, growth-regulating activities and changes in the blood parameters;

4) Isolation of the candidate compounds for subsequent advanced biological testing. Achieving the expected results is directly dependent on the purity of the compounds obtained.

List of full names of research team members with their identifiers (Scopus Author ID, Researcher ID, ORCID, if available) and links to relevant profiles

No

Full name, education, degree, academic title

Main work place, position

Hirsch Index, ResearcherID, ORCID, ScopusAuthor ID (if available)

Role in the project or program, and the nature of the work performed

1.

Ten Assel Yuriyevna

candidate of chemical sciences (PhD), associate professor

JSC “A.B. Bekturov ICS”, leading researcher

h-index: 3,

ResearcherID: AHD-4198-2022,

ORCID 0000-0002-9607-050X,

Scopus Author ID: 56306582600

Scientific Supervisor

2.

Yu Valentina Konstantinovna

doctor of chemical sciences, professor

JSC “A.B. Bekturov ICS”, chief researcher, Head of the Laboratory of chemistry of synthetic and natural medicinal substances

h-index: 7,

ResearcherID: ABF-3560-2021,

ORCID 0000-0001-6508-707X

Scopus Author ID: 8841069300

Executor

3.

Zharkynbek Tolganay Yerkinkyzy

master of engineering and technology

JSC “A.B. Bekturov ICS”, junior researcher

h-index: 2,

ResearcherID: GON-8241-2022,

ORCID 0000-0001-8884-5646,

Scopus Author ID: 57449317800

Executor

4.

Zhumakova Symbat Serikovna

PhD

JSC “A.B. Bekturov ICS”, scientific researcher

h-index: 2,

ResearcherID: AGP-1399-2022,

ORCID 0000-0002-4129-6931,

Scopus Author ID: 57193868170

Executor

5.

Zazybin Alexey Georgievich

PhD, professor

JSC “Kazakhstan-British Technical University”, professor

h-index: 9,

ResearcherID: ABF-3560-2021,

ORCID 0000-0002-6244-9327

Scopus Author ID: 6507879153

Executor

6.

Seilkhanov Tulegen Muratovich

candidate of chemical sciences (PhD), professor

NJSC “Kokshetau University named after Sh. Ualikhanov”, head of the Laboratory of engineering profile of NMR spectroscopy

h-index: 11,

ResearcherID: O-6399-2017,

ORCID 0000-0003-0079-4755,

Scopus Author ID: 55802144200

Executor

7.

Tursynova Bagila Galymzhankyzy

bachelor degree

JSC “A.B. Bekturov ICS”, engineer

h-index: 0,

ORCID 0000-0003-0229-0286

Executor

8.

Gubenko Maxim Andreevich

master in chemistry

NPO «Akhmet Baitursynuly Kostanay Regional University», senior lecturer

h-index: 1,

ResearcherID: JNS-2612-2023,

ORCID 0000-0002-4035-3500,

Scopus Author ID: 57385305900

Executor